“I know no safe depository of the ultimate powers of the society but the people themselves ; and if we think them not enlightened enough to exercise their control with a wholesome discretion, the remedy is not to take it from them, but to inform their discretion by education. This is the true corrective of abuses of constitutional power.” 

“Every generation needs a new revolution.”

“The dead should not rule the living.”

“Never spend your money before you have it.”

“Do not bite at the bait of pleasure till you know there is no hook beneath it.”

“Some men look at constitutions with sanctimonious reverence, and deem them like the ark of the covenant, too sacred to be touched. They ascribe to the men of the preceding age a wisdom more than human, and suppose what they did to be beyond amendment. I knew that age well; I belonged to it, and labored with it. It deserved well of its country. It was very like the present, but without the experience of the present; and forty years of experience in government is worth a century of book-reading; and this they would say themselves, were they to rise from the dead. I am certainly not an advocate for frequent and untried changes in laws and constitutions. I think moderate imperfections had better be borne with; because, when once known, we accommodate ourselves to them, and find practical means of correcting their ill effects. But I know also, that laws and institutions must go hand in hand with the progress of the human mind. As that becomes more developed, more enlightened, as new discoveries are made, new truths disclosed, and manners and opinions change with the change of circumstances, institutions must advance also, and keep pace with the times. We might as well require a man to wear still the coat which fitted him when a boy, as civilized society to remain ever under the regimen of their barbarous ancestors.” 

“Bigotry is the disease of ignorance, of morbid minds; enthusiasm of the free and buoyant. Education and free discussion are the antidotes of both. We are destined to be a barrier against the returns of ignorance and barbarism. Old Europe will have to lean on our shoulders, and to hobble along by our side, under the monkish trammels of priests and kings, as she can. What a Colossus shall we be when the Southern continent comes up to our mark! What a stand will it secure as a ralliance for the reason & freedom of the globe! I like the dreams of the future better than the history of the past. So good night. I will dream on, always fancying that Mrs Adams and yourself are by my side marking the progress and the obliquities of ages and countries.”

“I would rather be exposed to the inconveniences attending too much liberty than to those attending too small a degree of it.”

“Thomas Jefferson asked himself “In what country on earth would you rather live ” He first answered “Certainly in my own where are all my friends my relations and the earliest and sweetest affections and recollections of my life.” But he continued “which would be your second choice ” His answer “France.”

“History, I believe, furnishes no example of a priest-ridden people maintaining a free civil government. This marks the lowest grade of ignorance of which their civil as well as religious leaders will always avail themselves for their own purposes.”

“An enemy generally says and believes what he wishes.” 

“How much pain they have cost us, the evils which have never happened. --”

“The doctor of the future will give no medicine, but will interest his (sic)patient in the care of the human frame, in diet and in the cause and prevention of disease”

“The most fortunate of us, in our journey through life, frequently meet with calamities and misfortunes which may greatly afflict us; and, to fortify our minds against the attacks of these calamities and misfortunes, should be one of the principal studies and endeavours of our lives.”

“when you come to the end of your rope, tie a knot and hang on”