“He who permits himself to tell a lie once, finds it much easier to do it the second time.”

“It is an axiom in my mind, that our liberty can never be safe but in the hands of the people themselves, and that too of the people with a certain degree of instruction. This it is the business of the State to effect, and on a general plan.”

“A strict observance of the written laws is doubtless one of the highest virtues of a good citizen, but it is not the highest. The laws of necessity, of self-preservation, of saving our country when in danger, are of higher obligation. To lose our country by a scrupulous adherence to written law would be to lose the law itself, with life, liberty, property and all those who are enjoying them with us; thus absurdly sacrificing the end to the means.”

“Shake off all the fears of servile prejudices, under which weak minds are servilely crouched. Fix reason firmly in her seat, and call on her tribunal for every fact, every opinion. Question with boldness even the existence of a God; because, if there be one, he must more approve of the homage of reason than that of blindfolded fear.”

“As new discoveries are made, new truths discovered and manners and opinions change with the change of circumstances, institutions must advance also to keep pace with the times.”

“No man will ever bring out of that office the reputation which carries him into it. The honeymoon would be as short in that case as in any other, and its moments of ecstasy would be ransomed by years of torment and hatred.”

“The rights hereby asserted are of the natural rights of mankind, and that if any act shall be hereafter passed to repeal the present or to narrow its operation, such act will be an infringement of natural right.”

“The vote being passed, altho' further observn on it was out of order, he could not refrain from rising and expressing his satisfaction and concluded by saying "there is but one word, Mr. President, in the paper which I disapprove, & that is the word Congress," on which Ben Harrison rose and said "there is but on word in the paper, Mr. President, of which I approve, and that is the word Congress.”

“If you want something you've never had You must be willing to do something you've never done.” 

“The Christian god can easily be pictured as virtually the same god as the many ancient gods of past civilizations. The Christian god is a three headed monster cruel vengeful and capricious. If one wishes to know more of this raging three headed beast like god one only needs to look at the caliber of people who say they serve him. They are always of two classes fools and hypocrites. ”

“Some men look at constitutions with sanctimonious reverence, and deem them like the ark of the covenant, too sacred to be touched. They ascribe to the men of the preceding age a wisdom more than human, and suppose what they did to be beyond amendment. I knew that age well; I belonged to it, and labored with it. It deserved well of its country. It was very like the present, but without the experience of the present; and forty years of experience in government is worth a century of book-reading; and this they would say themselves, were they to rise from the dead. I am certainly not an advocate for frequent and untried changes in laws and constitutions. I think moderate imperfections had better be borne with; because, when once known, we accommodate ourselves to them, and find practical means of correcting their ill effects. But I know also, that laws and institutions must go hand in hand with the progress of the human mind. As that becomes more developed, more enlightened, as new discoveries are made, new truths disclosed, and manners and opinions change with the change of circumstances, institutions must advance also, and keep pace with the times. We might as well require a man to wear still the coat which fitted him when a boy, as civilized society to remain ever under the regimen of their barbarous ancestors.” 

“While the art of printing is left to us science can never be retrograde; what is once acquired of real knowledge can never be lost.”

“The doctor of the future will give no medicine, but will interest his (sic)patient in the care of the human frame, in diet and in the cause and prevention of disease”

“I'm a greater believer in luck, and I find the harder I work the more I have of it”

“I agree with yours of the 22d that a professorship of Theology should have no place in our institution. but we cannot always do what is absolutely best. those with whom we act, entertaining different views, have the power and the right of carrying them into practice. truth advances, & error recedes step by step only; and to do to our fellow-men the most good in our power, we must lead where we can, follow where we cannot, and still go with them, watching always the favorable moment for helping them to another step.