“Take things always by their smooth handle.”

“Man once surrendering his reason, has no remaining guard against absurdities the most monstrous, and like a ship without rudder, is the sport of every wind. With such persons, gullibility, which they call faith, takes the helm from the hand of reason, and the mind becomes a wreck.”

“The doctor of the future will give no medicine, but will interest his (sic)patient in the care of the human frame, in diet and in the cause and prevention of disease”

“Never trouble another for what you can do yourself”

“Some men look at constitutions with sanctimonious reverence, and deem them like the ark of the covenant, too sacred to be touched. They ascribe to the men of the preceding age a wisdom more than human, and suppose what they did to be beyond amendment. I knew that age well; I belonged to it, and labored with it. It deserved well of its country. It was very like the present, but without the experience of the present; and forty years of experience in government is worth a century of book-reading; and this they would say themselves, were they to rise from the dead. I am certainly not an advocate for frequent and untried changes in laws and constitutions. I think moderate imperfections had better be borne with; because, when once known, we accommodate ourselves to them, and find practical means of correcting their ill effects. But I know also, that laws and institutions must go hand in hand with the progress of the human mind. As that becomes more developed, more enlightened, as new discoveries are made, new truths disclosed, and manners and opinions change with the change of circumstances, institutions must advance also, and keep pace with the times. We might as well require a man to wear still the coat which fitted him when a boy, as civilized society to remain ever under the regimen of their barbarous ancestors.” 

“A great deal of love given to a few is better than a little to many.”

“The whole art of government consists in the art of being honest. Only aim to do your duty, and mankind will give you credit where you fail.”

“never trust a man who won't accept that there is more than one way to spell a word Paraphrased”

“The rights hereby asserted are of the natural rights of mankind, and that if any act shall be hereafter passed to repeal the present or to narrow its operation, such act will be an infringement of natural right.”

“Good humor is one of the preservatives of our peace and tranquility” 

“You have heard of the new chemical nomenclature endeavored to be introduced by Lavoisier, Fourcroy, &c. Other chemists of this country, of equal note, reject it, and prove in my opinion that it is premature, insufficient and false. These latter are joined by the British chemists; and upon the whole, I think the new nomenclature will be rejected, after doing more harm than good. There are some good publications in it, which must be translated into the ordinary chemical language before they will be useful.”

“They (religions) dread the advance of science as witches do the approach of daylight and scowl on the fatal harbinger announcing the subversions of the duperies on which they live.”

“Books constitute capital. A library book lasts as long as a house, for hundreds of years. It is not, then, an article of mere consumption but fairly of capital, and often in the case of professional men, setting out in life, it is their only capital.”

“Our civil rights have no dependence upon our religious opinions more than our opinions in physics or geometry.”

“The Tree of Liberty must be refreshed from time to time with the blood of patriots and tyrant. It is its natural manure.”